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KMID : 1138520050080030039
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Journal of Pharmacopuncture
2005 Volume.8 No. 3 p.39 ~ p.50
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A Comparative Study on the Etfects of {ulcorner}Palmisoyo-San;gamibang{lrcorner}, {ulcorner}Gyebu-Tang{lrcorner} and {ulcorner}Boganyangje{lrcorner} on the Thyrotoxicosis of Rats)
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Lee Yeun-Seong
Soh Kyung-Soon
Jeong Chan-Gil
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Abstract
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In order to study comparatively the effects of {ulcorner}Palmisoyo-San;gamibang(ø¢Ú«á¼é«ß¤Ê¥Ú«Û°){lrcorner}(AP), {ulcorner}Gyebu-Tang(Ìýݾ÷·){lrcorner}(GT) and {ulcorner}Boganyangje(ÜÍÊÜåÕð¥){\lrcorner}(BG) on the thyrotoxicosis rats, we have made thyrotoxicosis rat model by administration sodium levothyroxine p.o. during 4 days(Control group), and have administered solid extract of AP(236.8mg/200g/day : Sample I group), GT(80mg/200g/day : Sample II group) and BG(70.4mg/200g/day : Sample III group) p.o. to thyrotoxicosis rats during 3 days from 3rd day. We measured the body weight(BW), body temperature(BT), levels of Serum T_3{cdot}T_4{cdot}free;T_3{cdot}free;T_4 and TSH after administrating solid extract of AP, GT and BG. The results are summarized as follows: 1. Sample I group showed significantly high increasing rate compared with Control, Sample II and Sample III group, but it showed significantly lower levels of BT, T_4 and free T_4 than those of Control, Sample II and Sample III. group. 2. We could know that AP suppress the alteration of T_4 to T_3. 3. Sample II and Sample III group showed opposite results to Sample I group in the BW., BT, T_4 and free T_4 Especially Sample III was significantly higher than Control, Sample I and Sample II, so we could guess that BG stimulates the formation of thyroid hormones. According to the above experimental results, {ulcorner}Palmisoyo-San;gamibang(ø¢Ú«á¼é«ß¤Ê¥Ú«Û°){lrcorner} is assumed to have a curative effect against the thyrotoxicosis rat induced by sodium levothyroxine, and to suppress the alteration of T_4 to T_3. And we can suppose that {ulcorner}Boganyangje(ÜÍÊÜåÕð¥){lrcorner} has a curative effect against the hypothyroidism.
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KEYWORD
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Palmisoyo-San gamibang, Gyebu-Tang, Boganyangje, Body weight(BW), Body temperature(BT), Levels of SerumT_3, T_4, freeT_3, freeT_4andTSH
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